Mad scientist
Supply
Synergy
High (80)Engine 100%Slog 80%Trash-for-benefit 80%
Gardens/Silk Road + gainer + +Buy — Duke + Transmute
Cheap alt-VP piles score best when you can gain/buy many cards per turn to pad the deck count — the generalized Beggar/Gardens pattern.
Duke + Duchy-gainers — Duke + Transmute
Duke scores 1 VP per Duchy — cards that can gain Duchies directly accelerate it well past a normal buy plan.
Multiple Potion-cost piles — Alchemist + Transmute
A single Potion purchase amortizes across piles — a lone Potion-cost card is a cost, two or more is a plan.
Vineyard + cheap Action gainers — Vineyard + Transmute
Vineyard scores 1 VP per 3 Action cards — University/Workshops/Talisman stack Actions fast.
Victory-cards-matter + alt-VP rush — Duke + Great Hall
Crossroads/Shepherd-style payoffs for revealing/discarding Victory cards pair naturally with Gardens/Silk Road-style rush plans.
Extra piles
Bane