Mad scientist

Supply

Synergy

High (80)
Engine 100%Slog 80%Trash-for-benefit 80%
Gardens/Silk Road + gainer + +Buy Duke + Transmute

Cheap alt-VP piles score best when you can gain/buy many cards per turn to pad the deck count — the generalized Beggar/Gardens pattern.

Duke + Duchy-gainers Duke + Transmute

Duke scores 1 VP per Duchy — cards that can gain Duchies directly accelerate it well past a normal buy plan.

Multiple Potion-cost piles Alchemist + Transmute

A single Potion purchase amortizes across piles — a lone Potion-cost card is a cost, two or more is a plan.

Vineyard + cheap Action gainers Vineyard + Transmute

Vineyard scores 1 VP per 3 Action cards — University/Workshops/Talisman stack Actions fast.

Victory-cards-matter + alt-VP rush Duke + Great Hall

Crossroads/Shepherd-style payoffs for revealing/discarding Victory cards pair naturally with Gardens/Silk Road-style rush plans.

Extra piles

Bane